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˶*ԼPPTμ

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ʮ ˶*Լ 1 ʮ ˶*Լ һ ɭ ڶ С赸 ͢ٲ Ľ ζ״˱ * ˶*Լ 2 ˶*Լ(movement disorders),ֳΪ ׶ϵ(extrapyramidal diseases) һ˶ٻ˶쳣 Ʋ̬*˶֢״ΪҪֵϵͳ ׽ڲй 3 뼲йصĽʽṹ ׺ β״ Ǻ ԰ Ե׺ ά· ƤʡƤʻ· ʡ״廷· ״塪԰· 4 뼲йصĽʽṹ 5 ׽ڳ ׽ڲֵ˶쳣׶ϵ ֢״ Ϊ࣬쳣߻ͣ ˶ٻ 쳣˶赸֢Ͷ֢ 춯֢* һû̱о˶Ҳ 6 ׽ڳ -״ Ͱͨ· ǿֱ ٶ ɭ ۺ ״塢 ׺˲ ද 赸֢ Ͷ֢ 7 һ ɭ Parkinsons Disease 8 ɭʷع 11817꣺ӢҽJames Parkinson6״ ԡרԸò 2J.M.Charcot1877PDԡ̬* 3F.W. Lewy1913ʰڷ԰壬Ϊ· ףLewyС塣 4Hornykiewicz1960 ״DAŨ͡ 5Cotzias1967ӦͣL-DopaPD Ч 6Langstonȣ1983˹ϳMPTPɵPD 7Polymeropoulos(1997) Mizuno(1998)ȣPD Ļͻ䡣PDоȳ 9 Monograph by James Parkinson 1817 10 Alzheimer disease Parkinson disease 11 һ ɭ ɭParkinsons disease, PD ԣһֳ񾭱 ٴԾֹ˶ٻǿ ֱƲ̬*ΪҪ ҹ65ȺΪ1000/10 ӶߣԸŮ 12 һ ɭ / Ŵ Լ10%мʷΪɢԣ Ŀǰ6ɭ ²򱻿¡ 13 һ ɭ / ?MPTPһ񾭶1-׻4-1, 2, 3, 6-ण˺ͺշ͵ ɭۺ ?MPTPڻѧṹijЩɱͳ ƣΪ񾭶ṹ ƵĻѧʿɭIJ֮һ 14 һ ɭ / ϵͳϻ ?ɭҪ ?ʾ30Ժ ʶͰԪʼԱ ?ʶͰԪԱ̶뷢 й 15 һ ɭ / PDй, Ʋ Ŵ ϻ ɻ ˥ Ƴ ˷ܰ ϸ DA Ԫ ֢ ״ 16 һ ɭ / ֯ Ҫ ʶͰԪɫص Ԫʧ ϸڳ԰壬 ·С壨Lewy body 17 18 a. ή b. Parkinson a. Lewy H&E b.Bielschowsky Ⱦ 19 һ ɭ / ʶͰ ԪԶʧ -״ ͨ· ״Ͱ Ũͣ 80%) Ͱʽ ͵ij̶뻼 ߵ֢״ һ ֢ ״ 20 һ ɭ / Ͱ ׿ ״Ͱͣ ϵͳԿ 21 22 һ ɭ ٴ ?60Ժ󷢲ż30 ?𲡣չ һ֫ ͬ֫ Բ֫֫ 23 һ ɭ ٴ Ҫٴ˶֢״ ?1ֹstatic tremor ?2ǿֱrigidity ?3˶ٻbradykinesia ?4Ʋ̬* 24 һ ɭ ٴ Ҫٴ˶֢״ ?1о* ?2񾭹* ?3* 25 26 һ ɭ ?1.ѪԼҺ쳣 ?2.CTMRIԸı ?3.ӰPETSPECT ϼֵ 27 һ ɭ PET ʾټ 18F- 125I--CIT 99mTc-TRO DAT-1 123I-IBZM Ӱ Ͱʺϳɼ Ͱת壨DATڼ ٴڼʾ Ͱת壨DATڼ ٴڼʾ D2Ͱ幦 ڳʧ񾭳ڵ 28 һ ɭ PDзֻͻ 29



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